Figure 4

Measured concentrations and simulated fits of Atorvastatin compounds, individual 2. Displayed are the measured concentrations (rhombs) with mean and standard deviation (n = 3) of Atorvastatin compounds in the culture medium (upper two rows) and free Atorvastatin compounds inside primary hepatocytes (lower two rows) of individual 2, and corresponding simulation profiles (solid lines). First and third row: AS (left), ASpOH (middle) and ASoOH (right). Second and fourth row: ASL (left), ASLpOH (middle) and ASLoOH (right).