Figure 7
Distributions from dynamic analysis of the Inter-individual variability in Atorvastatin metabolism. Distributions (bars) of AUC (top), cmax (middle) and of t(cmax) (bottom), and fitted probability density functions of simulated profiles of AS (solid lines) and of the sum of AS, ASpOH and ASoOH (dashed lines), respectively. Distributions are predicted by the dynamic simulation of Atorvastatin metabolism, implementing individual CYP3A4 and UGT1A3 protein concentration data (Figure 6).