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Table 1 Recovery of atorvastatin metabolites in the time-series experiment on primary human hepatocytes of Individual 1

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

time [min] Recovery [%]
0 100
10 97.6
30 96.8
60 94.8
120 88.8
180 86.5
240 89.0
300 89.0
360 80.8
480 n.o.
600 78.2
  1. The recovery, calculated from material balance equations at each experimental time-point, is defined as the sum of intracellular and extracellular metabolite amounts divided by measured initial atorvastatin acid amount (n.o.: not observed) (see Additional file 3 - Atorvastatin metabolite concentrations from the time-series experiment on primary human hepatocytes of individual 1).