A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Table 1 Recovery of atorvastatin metabolites in the time-series experiment on primary human hepatocytes of Individual 1

The recovery, calculated from material balance equations at each experimental time-point, is defined as the sum of intracellular and extracellular metabolite amounts divided by measured initial atorvastatin acid amount (n.o.: not observed) (see Additional file 3 - Atorvastatin metabolite concentrations from the time-series experiment on primary human hepatocytes of individual 1).

ISSN: 1752-0509