BMC Systems Biology

Table 2 Parameters which were fixed in the optimization procedure to literature values

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Parameter	Value	Units	Literature
K_M,3A4,ASpOH	25600	pmol·ml^-1	[50]
K_M,3A4,ASoOH	29700	pmol·ml^-1	[50]
K_M,3A4,ASLpOH	1400	pmol·ml^-1	[50]
K_M,3A4,ASLoOH	3900	pmol·ml^-1	[50]
K_M,1B1,AS	18900	pmol·ml^-1	[54]
K_M,2B1,AS	200	pmol·ml^-1	[53]
K_M,1A3,AS	12000	pmol·ml^-1	[41]
K_I,1A3,AS	75000	pmol·ml^-1	[41]
k_CR	0.0025	min^-1	[43]
k_dis	600	min^-1	[33]

Parameter values were adopted from literature sources outlined in the right column.

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ISSN: 1752-0509

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