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Table 2 Parameters which were fixed in the optimization procedure to literature values

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Parameter Value Units Literature
KM,3A4,ASpOH 25600 pmol·ml-1 [50]
KM,3A4,ASoOH 29700 pmol·ml-1 [50]
KM,3A4,ASLpOH 1400 pmol·ml-1 [50]
KM,3A4,ASLoOH 3900 pmol·ml-1 [50]
KM,1B1,AS 18900 pmol·ml-1 [54]
KM,2B1,AS 200 pmol·ml-1 [53]
KM,1A3,AS 12000 pmol·ml-1 [41]
KI,1A3,AS 75000 pmol·ml-1 [41]
kCR 0.0025 min-1 [43]
kdis 600 min-1 [33]
  1. Parameter values were adopted from literature sources outlined in the right column.