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Table 3 Verified parameters of CYP3A4 and UGT1A3 in individual 1

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Parameter

Value

rel. Error [%]

Units

rmax,3A4,ASpOH

1108

5.5

pmol·min-1·ml-1

rmax,3A4,ASoOH

3345

2.3

pmol·min-1·ml-1

rmax,3A4,ASLpOH

1228

12.7

pmol·min-1·ml-1

rmax,3A4,ASLoOH

2756

11.6

pmol·min-1·ml-1

rmax,1A3,AS

956

14.8

pmol·min-1·ml-1

  1. Parameters are listed with nominal values from optimization and relative parameter errors from FIM based identifiability analysis (see Additional file 4 - Analysis of parameter sensitivity and following model reduction procedure) in the corresponding units shown.
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BMC Systems Biology

ISSN: 1752-0509

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