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Table 3 Verified parameters of CYP3A4 and UGT1A3 in individual 1

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Parameter Value rel. Error [%] Units
rmax,3A4,ASpOH 1108 5.5 pmol·min-1·ml-1
rmax,3A4,ASoOH 3345 2.3 pmol·min-1·ml-1
rmax,3A4,ASLpOH 1228 12.7 pmol·min-1·ml-1
rmax,3A4,ASLoOH 2756 11.6 pmol·min-1·ml-1
rmax,1A3,AS 956 14.8 pmol·min-1·ml-1
  1. Parameters are listed with nominal values from optimization and relative parameter errors from FIM based identifiability analysis (see Additional file 4 - Analysis of parameter sensitivity and following model reduction procedure) in the corresponding units shown.