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Table 5 Parameter Variability in the simultaneous model verification on individual atorvastatin metabolism data.

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Parameter Individual 1 Individual 2 Individual 3 Units
rmax,3A4,ASpOH 1108 660 606 pmol·min-1·ml-1
rmax,3A4,ASoOH 3345 1991 1830 pmol·min-1·ml-1
rmax,3A4,ASLpOH 1228 731 672 pmol·min-1·ml-1
rmax,3A4,ASLoOH 2756 1640 1508 pmol·min-1·ml-1
rmax,1A3,AS 957 281 120 pmol·min-1·ml-1
κPON,ASL 308 99.2 0.00 10-3 min-1
κPON,ASLOH 280 545 82.9 10-3 min-1
κex,AS 2.17 0.16 0.17 μL·min-1
κex,ASL 21.8 2.48 10.5 μL·min-1
κex,ASpOH, 0.80 1.25 0.52 μL·min-1
κex,ASoOH 1.60 3.62 0.91 μL·min-1
κex,ASLpOH 1.13 1.01 0.59 μL·min-1
κex,ASLoOH 2.67 86.3 0.77 μL·min-1
κim.AS 20.3 4.42 3.45 μL·min-1
κim.ASL 275 25.8 82.7 μL·min-1
κim,ASpOH 3.96 2.01 2.53 μL·min-1
κim,ASoOH 0.39 0.22 0.00 μL·min-1
κex,ASLpOH 33.7 7.24 8.59 μL·min-1
κim,ASLoOH 26.1 530 2.43 μL·min-1
kB-Ox,AS    15.0 10-3 min-1
kB-Ox,ASOH    0.00 10-3 min-1
  1. Parameters are listed for the individuals 1, 2 and 3 with nominal values from optimization in the corresponding units shown.