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Table 5 Parameter Variability in the simultaneous model verification on individual atorvastatin metabolism data.

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Parameter

Individual 1

Individual 2

Individual 3

Units

rmax,3A4,ASpOH

1108

660

606

pmol·min-1·ml-1

rmax,3A4,ASoOH

3345

1991

1830

pmol·min-1·ml-1

rmax,3A4,ASLpOH

1228

731

672

pmol·min-1·ml-1

rmax,3A4,ASLoOH

2756

1640

1508

pmol·min-1·ml-1

rmax,1A3,AS

957

281

120

pmol·min-1·ml-1

κPON,ASL

308

99.2

0.00

10-3 min-1

κPON,ASLOH

280

545

82.9

10-3 min-1

κex,AS

2.17

0.16

0.17

μL·min-1

κex,ASL

21.8

2.48

10.5

μL·min-1

κex,ASpOH,

0.80

1.25

0.52

μL·min-1

κex,ASoOH

1.60

3.62

0.91

μL·min-1

κex,ASLpOH

1.13

1.01

0.59

μL·min-1

κex,ASLoOH

2.67

86.3

0.77

μL·min-1

κim.AS

20.3

4.42

3.45

μL·min-1

κim.ASL

275

25.8

82.7

μL·min-1

κim,ASpOH

3.96

2.01

2.53

μL·min-1

κim,ASoOH

0.39

0.22

0.00

μL·min-1

κex,ASLpOH

33.7

7.24

8.59

μL·min-1

κim,ASLoOH

26.1

530

2.43

μL·min-1

kB-Ox,AS

  

15.0

10-3 min-1

kB-Ox,ASOH

  

0.00

10-3 min-1

  1. Parameters are listed for the individuals 1, 2 and 3 with nominal values from optimization in the corresponding units shown.