Probability density functions fitted to distributions of AUC, cmax and t(cmax) (depicted in Figure 7), generated in dynamic simulations considering inter-individual variability of CYP3A4 and UGT1A3 protein concentration data (Figure 6). Distributions of AUC, cmax and t(cmax) were fitted best with Log-logistic function. Displayed are the mean, the standard deviation (s.d.), and the relative standard deviation (rel. s.d.) of the fitted function, respectively.