A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Table 6 Probability density functions fitted to inter-individual variability distributions

	Probability density function	Mean	s.d.	rel. s.d. [%]
AUC [pmol ml ^-1 *min]
AS	Log-logistic	75051	92038	123
AS+ASpOH+ASoOH	Log-logistic	203617	35775	18
c _max [pmol ml ^-1 ]
AS	Log-logistic	201	64	32
AS+ASpOH+ASoOH	Log-logistic	366	10	3
t(c _max ) [min]
AS	Log-logistic	48	18	39
AS+ASpOH+ASoOH	Log-logistic	100	12	12

Probability density functions fitted to distributions of AUC, c_max and t(c_max) (depicted in Figure 7), generated in dynamic simulations considering inter-individual variability of CYP3A4 and UGT1A3 protein concentration data (Figure 6). Distributions of AUC, c_max and t(c_max) were fitted best with Log-logistic function. Displayed are the mean, the standard deviation (s.d.), and the relative standard deviation (rel. s.d.) of the fitted function, respectively.

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