
Probability density function

Mean

s.d.

rel. s.d. [%]


AUC [pmol ml
^{1}
*min]
    
AS

Loglogistic

75051

92038

123

AS+ASpOH+ASoOH

Loglogistic

203617

35775

18

c
_{
max
}
[pmol ml
^{1}
]
    
AS

Loglogistic

201

64

32

AS+ASpOH+ASoOH

Loglogistic

366

10

3

t(c
_{
max
}
) [min]
    
AS

Loglogistic

48

18

39

AS+ASpOH+ASoOH

Loglogistic

100

12

12

 Probability density functions fitted to distributions of AUC, c_{max} and t(c_{max}) (depicted in Figure 7), generated in dynamic simulations considering interindividual variability of CYP3A4 and UGT1A3 protein concentration data (Figure 6). Distributions of AUC, c_{max} and t(c_{max}) were fitted best with Loglogistic function. Displayed are the mean, the standard deviation (s.d.), and the relative standard deviation (rel. s.d.) of the fitted function, respectively.