A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer

Table 1 Gene Ontology Analysis of Estrogen Targets

ERα Target Mechanism	4 hour after E2 Stimulation			24 hour after E2 Stimulation
	Functional Category	P-value Range	N	Functional Category	P-value Range	N
Genomic	Gene Expression	2E-6 - 9E-3	26	Cellular Growth	4E-7 - 1E-2	96
	Cell Morphology	4E-6 - 1E-2	15	Cell Cycle	2E-6 - 1E-2	37
	Cellular Growth	3E-5 - 1E-2	37	Cell Death	4E-5 - 1E-2	70
	Cellular Development	5E-5 - 1E-2	22	Cellular Movement	5E-5 - 1E-2	46
	Cell Cycle	1E-4 - 1E-2	21	Cellular Development	6E-5 - 1E-2	48
Non-genomic	RNA Post-Transcription	5E-6 - 4E-2	5	DNA Replication, Recombination, and Repair	1E-9 - 3E-2	62
	Modification
	Cellular Development	8E-4 - 5E-2	2	Cell Cycle	1E-9 - 3E-2	70
	DNA Replication, Re-combination, and Repair	1E-3 - 4E-2	6	RNA Post-Transcription Modification	6E-6 - 2E-2	16
	Cellular Growth	1E-3 - 4E-2	8	Post-Transcription	5E-4 - 3E-2	15
	Amino Acid Metabolism	5E-3 - 5E-2	2	Modification Cellular Assembly and Organization	6E-4 - 3E-2	37

ISSN: 1752-0509