Figure 2

Normalised probability of network degree pairs. The axes represent the degree of interacting nodes (genes). The z axis scale indicates the ratio p(k1, k2)):pr(k1, k2). p(k1, k2) is the probability of observing an interacting pair of nodes in the MRSA network with degrees k1, k2 and pr(k1, k2) is same probability in the randomised MRSA network [102, 103]. Therefore, the bottom left area of the plot represents connections between nodes that have low degree values, the area at the top right represents connections between nodes that have high degree values. Individual pair values of p(k1, k2)):pr(k1, k2) range from to 0.01 to 34.0. Values given on x and y axes represent bin lower bounds, a cutoff was applied at degree of 70 due to degree pair sparseness above this value. The observed degree pair distribution reflects hierarchical structure with embedded modularity [34]. This figure was generated using R [95].