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Table 2 Significant virulence modules.

From: Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus

Module Summary

Genes annotated with GO:0009405 ('pathogenesis')

Additional Genes In Module

False discovery rate adjusted p-value

Colonization, immunomodulation

SAR1102 SAR0842 SAR2580 SAR0567 SAR2383 SAR2709 SAR2508 SAR2734

SAR0566 SAR0847 SAR1841 SAR1103 SAR1223 SAR2421 SAR1489 SAR1802

6.64E-8

Staphylococcal enterotoxins

SAR1920 SAR1919 SAR1916 SAR1921 SAR1917 SAR1918

-

1.69E-7

Superantigen-like proteins

SAR0424 SAR0427 SAR0425 SAR0422 SAR0423

SAR0426

7.10E-7

Two-component (sensor, response regulator) systems, drug resistance

SAR0670 SAR2448 SAR1426 SAR2447 SAR1427 SAR0758 SAR0669

SAR0068 SAR1772 SAR2167 SAR1771 SAR1567 SAR1332 SAR1331 SAR2449 SAR1568 SAR0019 SAR2450 SAR0760

2.38E-5

ESAT-6 system

SAR0283 SAR0282 SAR0284 SAR0279 SAR0281

SAR0285 SAR0287 SAR0288 SAR0289 SAR0290 SAR0291 SAR0286

4.92E-5

Superantigen-like proteins

SAR1141 SAR1140 SAR1139

-

6.36E-5

Superantigen-like proteins

SAR0431 SAR0428 SAR0429

-

6.36E-5

gamma-hemolysin

SAR2511 SAR2509 SAR2510

-

6.36E-5

Response regulators (MarR, SarR)

SAR2379 SAR0739 SAR2351

-

6.36E-5

Peptidases

SAR1022 SAR1020 SAR1021

SAR2716

2.22E-4

  1. Modules with false discovery rate corrected Fisher p-values ≤ 0.05 and size >2 are given. All modules were manually inspected with reference to literature and relevant databases (e.g. [30, 32]). Underlined locus identifiers were downregulated in response to ranalexin, none of the below loci were upregulated. Locus identifiers in bold are candidate novel virulence factors. Many genes that were not annotated with 'pathogenesis' in the Gene Ontology nevertheless had some association with virulence in the literature, and therefore are not indicated as candidate novel virulence factors in the table. Modules listed first 'Colonization, immunomodulation' and fifth 'ESAT-6 system' were also significant for the ranalexin downregulated gene set (Table 1).