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Figure 6 | BMC Systems Biology

Figure 6

From: BiologicalNetworks - tools enabling the integration of multi-scale data for the host-pathogen studies

Figure 6

User's Data integration. (A) User's Data Integration page allows integrate host-pathogen data which is interesting for particular user, but we didn't integrated. The integration procedure consists of three easy steps: 1) User registration, 2) Mapping of the data and 3) Integration of the data. We have integrated supplementary data provided in the studies of Konig et. al. [17] and others [2128]. (B) Meta-network model of the Konig et. al. data integrated (in A)) into the IntegromeDB database and available to be analyzed in concert with wealth of other host-pathogen data available in BiologicalNetworks [4042]. Host factors that were already present in our database and known to be related to viral response are colored green, whereas host factors newly discovered by Konig et. al. as being related to viral infection are colored red. Supplementary data from Konig et. al. integrated into our system are represented as colored meta-nodes (boxes): cyan- functional groups, yellow- molecular complexes, green - factors over-expressed after siRNA silencing, purple- biochemical complexes that are required by different RNA viruses, blue- host proteins confirmed to be required for wild-type influenza virus growth, pink -other virus experiments/publications (e.g. HIV, HCV, WNV, etc.) (see Supplementary data in Konig et. al.).

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