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Table 1 PCP-induced alterations in PFC metabolite levels as determined by SIEVE analysis

From: Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition

Formula

Metabolite

Metaboite

KEGG ID

KEGG

Pathways

P -value

Ratio

C 9 H 11 NO 3

L-Tyrosine

c00082

ko00350, ko00360, ko00400

0.001

0.584

C 10 H 17 N 3 O 6

gamma Glutamylglutamine

NA

NA

0.007

0.673

C 6 H 13 N 3 O 3

L-Citrulline

c00327

ko00330

0.007

0.709

C 3 H 7 NO 2 S

L-Cysteine

c00097

ko00260, ko00270, ko00430, ko00480, ko00730, ko00770, ko00920

0.012

0.445

C 8 H 9 NO

2-Phenylacetamide

c02505

ko00360

0.015

0.561

C 9 H 8 O 3

Phenylpyruvate

c00166

ko00360, ko00400

0.016

0.57

C 4 H 6 O 2

2,3-Butanedione

c00741

map00650

0.017

0.786

C 4 H 5 N 3 O

Cytosine

c00380

ko00240

0.019

0.665

C 04 H 9 NO 2

GABA

c00334

ko00250, ko00330, ko00410, ap00650, ko04080

0.021

0.804

C 9 H 17 NO 4

O-Acetylcarnitine

c02571

ko00250

0.022

2.649

C 14 H 18 N 5 O 11 P

Adenylosuccinate

c03794

ko00230, ko00250

0.029

3.276

C 5 H 5 N 5 O

Guanine

c00242

ko00230

0.035

0.593

C 7 H 16 NO 3

Carnitine

c00487

ko00310

0.037

0.819

  1. Table 1 shows the molecular formula, tentative metabolite identity and the KEGG pathways in which a metabolite is involved. Only metabolites found to be significantly different between the two experimental groups by SIEVE analysis (see Methods section) are shown. Full data for all metabolites detected in the PFC of control and PCP-treated rats are shown in Table S1 (Additional File 1). The most prominent alterations in KEGG defined metabolic pathways appeared to be in (i) alanine, aspartate and glutamate metabolism (3 metabolites [ko00250]), (ii) phenylalanine, tyrosine and tryptophan metabolism (3 metabolites [ko00360]), (iii) purine metabolism (2 metabolites [ko00230]) and (iv) butanoate metabolism (2 metabolites [ko00650]). KEGG defined metabolic pathways; ko00250: Alanine, Aspartate and Glutamate metabolism; ko00330: Arginine and Proline metabolism; ko00410: beta-Alanine metabolism; map00650: Butanoate metabolism; ko00270: Cysteine and Methionine metabolism; k00480: Glutathione metabolism; ko00260: Glycine, Serine and Threonine metabolism; ko00430: Methionine metabolism; ko04080; Neuroactive ligand-receptor interaction; ko00770: Pantoate and CoA biosynthesis; ko00360: Phenylalanine metabolism; ko00400: Phenylalanine, Tyrosine and Tryptophan biosynthesis; ko00230: Purine metabolism; ko00240: Pyrimidine metabolism; ko00920: Sulphur metabolism; ko00430: Taurine and Hypotaurine metabolism; ko00730: Thiamine metabolism; ko00350: Tyrosine metabolism; ko00400: Tyrosine and Tryptophan biosynthesis. NA denotes a metabolite not associated with a KEGG compound ID or KEGG pathway.
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BMC Systems Biology

ISSN: 1752-0509

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