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Figure 2 | BMC Systems Biology

Figure 2

From: Expanding a dynamic flux balance model of yeast fermentation to genome-scale

Figure 2

idFV715 model performance. Model predictions of consumption and production rates of the main metabolites and nutrients involved in an alcoholic fermentation. In this figure, symbols represent the experimental data and lines represent model prediction. Measured values were in triplicate with a CV <5%: A: Experiments and simulations of isothermal, laboratory-scale fermentations, in 4 conditions of total-assimilable-nitrogen (100, 200, 300, 400 mg/L of YAN); B: Experiments and simulations of isothermal, laboratory-scale, high-nitrogen fermentations (300 mg/L of YAN, R = 99%, 400 points), 28°C; C: Experiments and simulations of isothermal, laboratory-scale, high-nitrogen fermentations. Residual sugar concentration at two representative initial conditions of sugar content in the medium (240 and 182 g/L, 300 mg/L YAN, 28°C); D: Experiments and simulations of anisothermal, industrial-scale, high-nitrogen (240 mg/L YAN) fermentations. The fastest and slowest fermentations are shown. Simulations werefile run assuming a typical temperature profile (dotted-line); E: Isothermal, laboratory-scale, residual sugar concentration for the fastest and the slowest fermentation analyzed, corresponding to 50 mg/L YAN and 300 mg/L, respectively; F: Isothermal, laboratory-scale, predicted concentration of biomass under 50 mg/L (closed circles) YAN and 300 mg/L (×) YAN 28°C; G: Isothermal, laboratory-scale, predicted concentration of ethanol (×) and glycerol (closed circles) under 240 g/L sugar, 300 mg/L YAN, 28°C; H: Isothermal, laboratory-scale, predicted concentration of ethanol (×) and glycerol (closed circles) under 182 g/L sugar, 300 mg/L YAN, 28°C.

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