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Table 1 Statistical measures for the predicted two subtypes of Breast cancer*.

From: Modularity-based credible prediction of disease genes and detection of disease subtypes on the phenotype-gene heterogeneous network

Disease subtypes
(Disease subgroup)
Number of gene pairs with high topological similarity
MHT(g, g') <θ R )
Number of gene pairs with low topological similarity
MHT(g, g') >θ R )
P value#
Within subgroup 1 56 64 P1<0.0001
Within subgroup 2 333 570 P2<0.0001
Between subgroups 1 and 2 128 480  
  1. *: We assess the modularity level of the predicted disease subtypes by comparing topological similarity of gene pairs within each subgroup to gene pairs between the two subgroups.
  2. #: The P value of disease subgroup 1 (P1) and the P value of disease subgroup 2 (P2) are calculated using the Fisher's Exact Test.
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