Modularity-based credible prediction of disease genes and detection of disease subtypes on the phenotype-gene heterogeneous network

Table 1 Statistical measures for the predicted two subtypes of Breast cancer*.

Disease subtypes (Disease subgroup)	Number of gene pairs with high topological similarity MHT(g, g') <θ_R)	Number of gene pairs with low topological similarity MHT(g, g') >θ_R)	P value#
Within subgroup 1	56	64	P₁<0.0001
Within subgroup 2	333	570	P₂<0.0001
Between subgroups 1 and 2	128	480

*: We assess the modularity level of the predicted disease subtypes by comparing topological similarity of gene pairs within each subgroup to gene pairs between the two subgroups.
#: The P value of disease subgroup 1 (P₁) and the P value of disease subgroup 2 (P₂) are calculated using the Fisher's Exact Test.

ISSN: 1752-0509