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Figure 2 | BMC Systems Biology

Figure 2

From: Improved functional overview of protein complexes using inferred epistatic relationships

Figure 2

Similarity threshold vs accuracy: the impact of the similarity threshold on the accuracy of the predicted S-scores, as measured by correlation between predicted and experimentally observed values (A) and NRMSE (B). (C) is a density plot showing agreement between independent E-MAP experiments [32, 34] and agreement between observed and predicted interactions at thresholds 0.8 (D), 0.6 (E) and 0.4 (F). Lines are drawn at the thresholds which have previously been used to identify 'significantly negative' and 'significantly positive' interactions [33]. Interactions in the light green boxes indicate values which should be positive or negative, which have been predicted as neutral(and vice versa). Interactions in the dark green boxes indicate values whose polarity has been switched -- significant negatives predicted as positives and vice versa.

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