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Figure 5 | BMC Systems Biology

Figure 5

From: Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization

Figure 5

The expression perturbation patterns induced by BMP6 treatment in nine significant GO term gene sets. Each of these GO term gene sets is significant in at least one time point based on GAGE. (a) GO:0007219 Notch signaling pathway, GO:0005520 insulin-like growth factor binding, GO:0005159 insulin-like growth factor receptor binding, GO:0008430 selenium binding, (b) GO:0007156 homophilic cell adhesion, GO:0006955 immune response, GO:0001501 skeletal development, GO:0001503 ossification, GO:0016491 oxidoreductase activity. The mean t-statistic from multiple one-on-one comparisons between the two sample conditions is used as a measure of the overall perturbation for each GO term. Different from KEGG pathways, perturbation direction is considered here. The dashed lines mark t = +/-1.30, which roughly correspond to p = 0.05 for 8-96 h or 0.01 for 10 d.

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BMC Systems Biology

ISSN: 1752-0509

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