Table 1 Interpretation and validation of the significant KEGG pathways inferred by GAGE.
| KEGG pathways | Most perturbed | References | Other evidences |
|---|---|---|---|
| TGF-beta signaling pathway | 8h | [5, 57] | BMP signal targets IDs, SMAD6-7, DLX5 extremely up |
| Cytokine-cytokine receptor interaction | 8h | [33, 58] | IFN target gene sets down (Table 4) |
| Wnt signaling pathway | 8h | [59, 60] | |
| Jak-STAT signaling pathway | 24h | [58, 61] | STAT1 target genes down |
| MAPK signaling pathway | 24h | [22, 23] | -- |
| p53 signaling pathway | 24h | [62, 63] | -- |
| Focal adhesion | 10d | [20, 21] | -- |
| ECM-receptor interaction | 10d | [64, 65] | -- |