Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization

Table 2 The overlaps in perturbed member genes between the significant KEGG pathways inferred by GAGE

	TGFb	Cyto	Wnt	MAPK	Jak	p53	Focal	ECM
TGFb	0 (22)	5.6E-20(8)	3.3E-06(2)	4.3E-10(4)	3.1E-04(1)	3.1E-04(1)	2.9E-06(2)	4.1E-05(1)
Cyto	5.6E-20(8)	0(34)	1 (0)	3.4E-11(5)	8.3E-29(11)	1 (0)	6.4E-10(4)	1 (0)
Wnt	3.3E-06(2)	1 (0)	0 (24)	6.9E-10(4)	2.9E-06(2)	3.5E-09(3)	2.3E-08(3)	1 (0)
MAPK	4.3E-10(4)	3.4E-11(5)	6.9E-10(4)	0 (33)	7.0E-04(1)	2.7E-06(2)	5.5E-10(4)	1 (0)
Jak	3.1E-04(1)	8.3E-29(11)	2.9E-06(2)	7.0E-04(1)	0 (21)	1.4E-04(1)	3.4E-04(1)	1 (0)
p53	3.1E-04(1)	1 (0)	3.5E-09(3)	2.7E-06(2)	1.4E-04(1)	0 (15)	3.0E-09(3)	1.9E-05(1)
Focal	2.9E-06(2)	6.4E-10(4)	2.3E-08(3)	5.5E-10(4)	3.4E-04(1)	3.0E-09(3)	0 (23)	2.1E-24(7)
ECM	4.1E-05(1)	1 (0)	1 (0)	1 (0)	1 (0)	1.9E-05(1)	2.1E-24(7)	0 (8)

For each cell in the table, in the parenthesis is the number of perturbed member genes overlapping between the significant KEGG pathways; outside is the significance of this overlap between KEGG pathways. Details of overlap analysis are given in Methods section. Full names for these KEGG pathways are: TGF-beta signaling pathway (TGFb), Cytokine-cytokine receptor interaction (Cyto), Wnt signaling pathway (Wnt), MAPK signaling pathway (MAPK), Jak-STAT signaling pathway (Jak), p53 signaling pathway (p53), Focal adhesion (Focal), ECM-receptor interaction (ECM).

ISSN: 1752-0509