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Table 3 Interpretation and validation information of the significant GO term gene sets inferred by GAGE

From: Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization

GO terms Perturbation References Other evidence
Notch signaling pathway 8h-10d up [11, 25] --
insulin-like growth factor receptor binding 8h-10d up [26, 27] --
insulin-like growth factor binding 10d down [2831] --
homophilic cell adhesion 24h-96h up [34] --
immune response 96h-10d down [32, 33] --
skeletal development 8h-96h up -- --
ossification 96h-10d up -- --
oxidoreductase activity 8h-24h, 10d down [35] --
selenium binding 96h-10d up -- --
  1. Temporal perturbation patterns (significantly perturbed time period and the direction), supportive literature and experimental evidence all suggest the regulatory roles of these GO terms in BMP6 induced osteoblast differentiation and mineralization.