Experimental sets | Significant | References | Other evidences |
|---|
MYB targets | 8h-24h,10d down | [37, 38] | Wnt signal (KEGG) |
BAF57 down | 8h-24h,10d down | [39–42] | BAF57 up |
BAF57 up | 24h-96h up | [39–42] | BAF57 down |
IFNb up | 8h,10d down | -- | Jak-STAT signal (KEGG) |
VEGF up | 10d down | [43] | MYB targets |
IRS down | 8h-10d down | -- | IGF signal (GO) |
- Temporal perturbation patterns, supportive literature works and extra experimental evidences all suggest the regulatory roles of these experimental sets in BMP6 induced osteoblast differentiation and mineralization. Experimental sets came from MSigDB [51] c2 collection, where the original names for these significant gene sets are: Lei_MYB_Regulated_Genes, BAF57_BT549_Dn, BAF57_BT549_Up; (B) Der_IFNB_Up, VEGF_Mmmec_6hrs_Up, IRS_Ko_Adip_Up (down regulated by IRS since up-regulated upon IRS knock down).
