Table 2 Virulence factors incorporated in the metabolic network reconstruction of B. cenocepacia J2315

Lipopolysaccharide components

   Lipid A

LpxA, LpxB, LpxC, LpxD, LpxH, LpxK, KdsA, KdsB, KdsC, KdtA, KdoO, HtrB

O_2,

UDP-N-acetyl-D-glucosamine,

(R)-3-Hydroxytetradecanoyl-ACP,

(R)-3-Hydroxyhexadecanoyl-ACP,

Myristoyl-ACP,

D-arabinose 5-phosphate,

Phosphoenolpyruvate,

   Core oligosaccharide

GmhA, RfaE, GmhB, HldD, RmlD, WbiI, WaaC, WaaF, WabP, WabR, WabO, WabS, WaaL

Sedoheptulose 7-phosphate,

UDP-glucose,

UDP-N-acetyl-D-glucosamine,

dTDP-4-dehydro-6-deoxy-L-mannose,

L-Alanine

   Ara4N modification

ArnA1, ArnA2, ArnB, ArnC, ArnT

L-Glutamate,

10-Formyltetrahydrofolate,

UDPglucuronate

Quorum sensing

   AHLs

CepI, CciI

S-adenosyl-L-methionine,

Octanoyl-ACP,

Hexanoyl-ACP

   HHQ

KynA, KynB, KynU, PqsA, PqsB, PqsC, PqsD

L-Tryptophan,

3-oxodecanoyl-ACP

   BDSF

RpfF, FadA, FadB, FadH

(S)-Hydroxydecanoyl-CoA

Rhamnolipids

RhlA, RhlB, RhlC, PhaC

dTDP-4-dehydro-6-deoxy-L-mannose,

(R)-3-Hydroxydecanoyl-ACP