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Table 2 Virulence factors incorporated in the metabolic network reconstruction of B. cenocepacia J2315

From: Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction

Virulence factors Proteins involved Major metabolic precursors
Lipopolysaccharide components   
   Lipid A LpxA, LpxB, LpxC, LpxD, LpxH, LpxK, KdsA, KdsB, KdsC, KdtA, KdoO, HtrB O2, UDP-N-acetyl-D-glucosamine, (R)-3-Hydroxytetradecanoyl-ACP, (R)-3-Hydroxyhexadecanoyl-ACP, Myristoyl-ACP, D-arabinose 5-phosphate, Phosphoenolpyruvate,
   Core oligosaccharide GmhA, RfaE, GmhB, HldD, RmlD, WbiI, WaaC, WaaF, WabP, WabR, WabO, WabS, WaaL Sedoheptulose 7-phosphate, UDP-glucose, UDP-N-acetyl-D-glucosamine, dTDP-4-dehydro-6-deoxy-L-mannose, L-Alanine
   Ara4N modification ArnA1, ArnA2, ArnB, ArnC, ArnT L-Glutamate, 10-Formyltetrahydrofolate, UDPglucuronate
Quorum sensing   
   AHLs CepI, CciI S-adenosyl-L-methionine, Octanoyl-ACP, Hexanoyl-ACP
   HHQ KynA, KynB, KynU, PqsA, PqsB, PqsC, PqsD L-Tryptophan, 3-oxodecanoyl-ACP
   BDSF RpfF, FadA, FadB, FadH (S)-Hydroxydecanoyl-CoA
Rhamnolipids RhlA, RhlB, RhlC, PhaC dTDP-4-dehydro-6-deoxy-L-mannose, (R)-3-Hydroxydecanoyl-ACP
  1. Ara4N, 4-amino-4-deoxy-arabinose; AHLs, N-acylhomoserine lactones; HHQ, 2-heptyl-4-quinolone; BDSF, cis-2-dodecenoic acid