Systems mapping: how to improve the genetic mapping of complex traits through design principles of biological systems

Table 2 Means of maximum likelihood estimates of curve parameters from the ODE system (1) and their biases, standard deviations (STD) and square root mean square errors (RMSE) from 100 simulation replicates.

Genotype	Estimate	α _L	β _L	γ _L	α _S	β _S	α _R	β _R	γ _R
QQ	TRUE	2.55	0.10	0.31	0.98	0.04	1.11	0.51	2.18
	MEAN	2.55	0.10	0.31	0.98	0.04	1.11	0.51	2.18
	BIAS*10³	2.10	-0.07	0.72	0.27	0.01	3.49	-0.88	-2.89
	STD*10²	3.75	0.08	0.60	0.94	0.01	1.29	0.49	1.11
	RMSE*10²	3.75	0.08	0.61	0.94	0.01	1.34	0.50	1.15
qq	TRUE	1.89	0.14	0.44	1.04	0.07	1.11	0.56	1.85
	MEAN	1.89	0.14	0.44	1.04	0.07	1.11	0.56	1.85
	BIAS*10³	-4.23	0.11	0.55	-0.61	-0.05	1.62	0.92	-2.02
	STD*10²	3.60	0.14	0.92	0.99	0.04	1.38	0.45	1.66
	RMSE*10²	3.62	0.14	0.92	0.99	0.04	1.39	0.46	1.67

ISSN: 1752-0509