Figure 8

Single-drug response curves. The figure shows an evaluation of the model-predicted ATP-levels of A549 and AG02603 when the concentrations of three drugs are held constant while the concentration of the fourth drug is varied. The values of the concentration at which the three drugs are held constant are shown in Table 3. Shown are the single-drug effects of increasing concentrations of (A) AG490, (B) U0126, (C) indirubin-3'-monoxime and (D) GF 109203X on cellular ATP-level with respect to different levels of the other three drugs in the treatment. Here the second row fourth column subfigure corresponds to the cellular ATP-levels of A549 and AG02603 to varying concentrations of U0126 while the remaining three other drugs are held at the selected concentration in Table 3.