Table 1 Description and range of the parameters varied in the simulations with the mammalian circadian clock model

v_mB

nMh^-1

Maximum rate of Bmal1 mRNA degradation

0.16

0.017

0.28

v_mC

nMh^-1

Maximum rate of Cry mRNA degradation

0.80

0.086

1.40

v_mP

nMh^-1

Maximum rate of Per mRNA degradation

0.88

0.094

1.54

v_dPCN

nMh^-1

Maximum rate of degradation of nuclear phosphorylated Per-Cry complex

0.80

0.086

1.40

v_dIN

nMh^-1

Maximum rate of degradation of nuclear Per-Cry-Clock-Bmal1 complex

0.64

0.069

1.12

k₁

h^-1

Rate constant for entry of the Per-Cry complex into the nucleus

0.64

0.069

1.12

k₃

nM^-1h^-1

Rate constant for the formation of the Per-Cry complex

0.64

0.069

1.12

k₅

h^-1

Rate constant for entry of the Bmal1 protein into the nucleus

0.32

0.034

0.56

k₇

nM^-1h^-1

Rate constant for the formation of the inactive Per-Cry-Clock-Bmal1 complex

0.40

0.043

0.70