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Table 1 Description and range of the parameters varied in the simulations with the mammalian circadian clock model

From: Hierarchical Cluster-based Partial Least Squares Regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models

Parameter name Unit Description Minimum value Level step size Maximum value
vmB nMh-1 Maximum rate of Bmal1 mRNA degradation 0.16 0.017 0.28
vmC nMh-1 Maximum rate of Cry mRNA degradation 0.80 0.086 1.40
vmP nMh-1 Maximum rate of Per mRNA degradation 0.88 0.094 1.54
vdPCN nMh-1 Maximum rate of degradation of nuclear phosphorylated Per-Cry complex 0.80 0.086 1.40
vdIN nMh-1 Maximum rate of degradation of nuclear Per-Cry-Clock-Bmal1 complex 0.64 0.069 1.12
k1 h-1 Rate constant for entry of the Per-Cry complex into the nucleus 0.64 0.069 1.12
k3 nM-1h-1 Rate constant for the formation of the Per-Cry complex 0.64 0.069 1.12
k5 h-1 Rate constant for entry of the Bmal1 protein into the nucleus 0.32 0.034 0.56
k7 nM-1h-1 Rate constant for the formation of the inactive Per-Cry-Clock-Bmal1 complex 0.40 0.043 0.70