Cell functional enviromics: Unravelling the function of environmental factors

BMC Systems Biology

Table 2 Ranking of statistically significant EMs for sequential metabolic phases of fed-batch 3

Phase I		Phase II		Phase III		Phase IV		Phase V
EM	Var (%)	EM	Var (%)	EM	Var (%)	EM	Var (%)	EM	Var (%)
110	61.76	250	65.02	62	47.28	62	80.69	62	84.30
6	69.92	1	89.68	1	90.61	12	85.98	6	89.43
11	75.82	41	93.81	11	92.80	1	89.37	1	94.44
-7	81.63	28	96.57	6	93.96	86	91.08	49	97.04
2	87.34	43	97.04	80	95.61	5	92.29	201	97.53
5	91.93	-4	97.40	5	96.28	43	93.11	119	97.84
4	94.05	5	97.63	43	96.86	7	93.48	-4	98.14
101	95.86	47	97.84	7	97.07	6	93.88	11	98.43
43	96.45	6	98.01	201	97.14	69	94.00	43	98.67
1	97.02	11	98.13	-4	97.22	11	94.12	102	98.87
86	97.55	80	98.24	3	97.27	225	94.16	5	98.95
45	97.67	102	98.29	45	97.31	-4	94.19	7	99.03
33	97.77	15	98.31	102	97.34	102	94.27	87	99.11
24	97.83	7	97.34	86	97.35	79	94.30	15	99.15
41	97.89	87	97.35	81	97.36			37	99.23
74	97.91	10	97.36	88	97.37			14	99.27
3	97.92	9	97.37

The minus sign indicates flux in the opposite direction for those EMs whose participating reactions are all reversible. EMs in bold were conserved between cultures and also selected from the full data set (see Figure 2b), showing the ability of the PLP algorithm to identify essential common features in metabolism.

ISSN: 1752-0509