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Table 2 Ranking of statistically significant EMs for sequential metabolic phases of fed-batch 3

From: Cell functional enviromics: Unravelling the function of environmental factors

Phase I Phase II Phase III Phase IV Phase V
EM Var (%) EM Var (%) EM Var (%) EM Var (%) EM Var (%)
110 61.76 250 65.02 62 47.28 62 80.69 62 84.30
6 69.92 1 89.68 1 90.61 12 85.98 6 89.43
11 75.82 41 93.81 11 92.80 1 89.37 1 94.44
-7 81.63 28 96.57 6 93.96 86 91.08 49 97.04
2 87.34 43 97.04 80 95.61 5 92.29 201 97.53
5 91.93 -4 97.40 5 96.28 43 93.11 119 97.84
4 94.05 5 97.63 43 96.86 7 93.48 -4 98.14
101 95.86 47 97.84 7 97.07 6 93.88 11 98.43
43 96.45 6 98.01 201 97.14 69 94.00 43 98.67
1 97.02 11 98.13 -4 97.22 11 94.12 102 98.87
86 97.55 80 98.24 3 97.27 225 94.16 5 98.95
45 97.67 102 98.29 45 97.31 -4 94.19 7 99.03
33 97.77 15 98.31 102 97.34 102 94.27 87 99.11
24 97.83 7 97.34 86 97.35 79 94.30 15 99.15
41 97.89 87 97.35 81 97.36    37 99.23
74 97.91 10 97.36 88 97.37    14 99.27
3 97.92 9 97.37       
  1. The minus sign indicates flux in the opposite direction for those EMs whose participating reactions are all reversible. EMs in bold were conserved between cultures and also selected from the full data set (see Figure 2b), showing the ability of the PLP algorithm to identify essential common features in metabolism.