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Table 3 Stoichiometry of macroscopic reactions obtained from the elementary flux modes discriminated in Figures 2b and Tables 2, 5 and 5

From: Cell functional enviromics: Unravelling the function of environmental factors

EM 1

0.052 Gln + 0.048 Glu + 0.034 Ala + 0.033 Asp + 0.073 Ser + 0.035 Asn + 0.028 Gly + 0.026 His + 0.065 Thr + 0.049 Arg + 0.073 Pro + 0.069 Tyr + 0.016 Cys + 0.081 Val + 0.015 Met + 0.037 Ile + 0.109 Leu + 0.081 Lys + 0.065 Phe → IgG1-IL2

EM 2

His → Glu + Amm

EM 3

Phe → Tyr

EM 4

Gln → Glu + Amm

EM 5

Glu → Pro

EM 6

Ser + Amm → 2 Gly

EM 7

Asn → Asp + Amm

EM 9

Glu → Ala + 5 CO2

EM 11

Glc → 2 Lac

EM 12

Ser → Lac + Amm

EM 19

413 Glc + 311 Gln + 213 Ala + 215 Asp + 183 Ser + 114 Asn + 253 Gly + 56 His + 148 Thr + 153 Arg + 136 Pro + 67 Tyr + 72 Cys + 155 Val + 65 Met + 109 Ile + 209 Leu + 175 Lys + 82 Phe → Biomass + 23 Glu

EM 20

126 Glc + 311 Gln + 213 Ala + 215 Asp + 758 Ser + 114 Asn + 253 Gly + 56 His + 148 Thr + 153 Arg + 136 Pro + 67 Tyr + 72 Cys + 155 Val + 65 Met + 109 Ile + 209 Leu + 175 Lys + 82 Phe → Biomass + 23 Glu + 575 Amm

EM 21

126 Glc + 311 Gln + 213 Ala + 215 Asp + 183 Ser + 114 Asn + 253 Gly + 56 His + 148 Thr + 153 Arg + 136 Pro + 67 Tyr + 72 Cys + 155 Val + 65 Met + 109 Ile + 209 Leu + 175 Lys + 82 Phe + 575 Lac → Biomass + 23 Glu

EM 42

Cys → Amm + 3 CO2

EM 43

Glc → 6 CO2

EM 45

Lac → 3 CO2

EM 62

126 Glc + 311 Gln + 213 Ala + 215 Asp + 758 Ser + 114 Asn + 253 Gly + 56 His + 148 Thr + 153 Arg + 136 Pro + 67 Tyr + 72 Cys + 155 Val + 65 Met + 109 Ile + 209 Leu + 175 Lys + 82 Phe + 552 Glu → Biomass + 575 Amm

EM 74

Asp → Amm + 5 CO2

EM 98

442 Glc + 311 Gln + 213 Ala + 215 Asp + 758 Ser + 114 Asn + 253 Gly + 56 His + 148 Thr + 153 Arg + 136 Pro + 67 Tyr + 72 Cys + 155 Val + 65 Met + 109 Ile + 209 Leu + 175 Lys + 82 Phe + 552 Glu + 56 Amm → Biomass + 23 Glu

EM 100

126 Glc + 311 Gln + 213 Ala + 215 Asp + 758 Ser + 114 Asn + 253 Gly + 56 His + 148 Thr + 153 Arg + 136 Pro + 67 Tyr + 72 Cys + 155 Val + 65 Met + 109 Ile + 209 Leu + 175 Lys + 82 Phe + 632 Glu + 56 Amm → Biomass + 23 Glu

EM 102

Ser + Met → Amm + Glu + 3 CO2

  1. The stoichiometry of EM macroscopic reactions considers only extracellular compounds, and is readily calculated as described in Methods. Some of these pathways involve only a single intracellular reaction able to operate in steady-state, whenever all the metabolites involved are also present extracellularly.