Transcription Factor
|
cell line
|
tissue of origin
|
peaks near TSS of the genes of the extended network
|
peaks near TSS reported on SwitchGear
|
p-value
|
---|
Pol2
|
HeLa-S3
|
cervical
|
608
|
7766
|
2.15E-067
|
TCF4
|
HCT-116
|
colorectal
|
455
|
5543
|
1.93E-050
|
E2F6
|
k562
|
Leukemia
|
488
|
6343
|
1.12E-046
|
Max
|
HeLa-S3
|
cervical
|
313
|
3375
|
2.90E-042
|
c-Myc
|
HeLa-S3
|
cervical
|
250
|
2395
|
1.88E-041
|
NFKB
|
GM12878
|
Lymphoblastoid
|
195
|
1802
|
6.78E-034
|
E2F1-HA
|
HeLa-S3
|
cervical
|
315
|
4272
|
7.57E-024
|
- ChIP-Seq peaks mapped to regions corresponding to the promoter sequences as considered for this study (-700, 300 bp), based upon transcription start sites (TSS) annotated by SwitchGear. Peaks near TSS of the genes of the extended network and reported on SwitchGear refers to the amount of peaks found in the corresponding promoter regions. P-values were calculated by a hypergeometric test. Sample size was considered as the amount of genes that corresponded to the proteins of the extended network. Population size was the number of reported TSS reported on SwitchGear with a score greater than 20.