Figure 1

Pipeline of NIMS: ranking the synergistic effect of n agents paired with a given agent. For a given agent (Agent _x ) and n candidate agents (Agent ₁ , …, Agent _n ), all agent genes are collected and mapped to a disease network target. For each agent (Agent ₁ , …, Agent _n ) combined with Agent _x , TS (Topology Score) is obtained by calculating the node importance of both sets of agent genes and the shortest path between them. TS is subsequently weighed by the AS (Agent Score) of each agent pair to ultimately produce S (Synergy score), which is used to rank the synergy strength for the n candidate agents matched with the given Agent _x .