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Table 1 NIMS ranks against four types of background networks

From: Network target for screening synergistic drug combinations with application to traditional Chinese medicine

  

Rank among 62 agent pairs #

Given agent

Partner agent

Angiogenesis network (NIMS score)

PPI

KNC

MNC

5-fluorouracil

Vinblastine*

2 (0.18104)

1

2

2

 

Rapamycin*

3 (0.13744)

2

3

26

Vinblastine

Camptothecin*

1 (0.19927)

1

1

3

Genistein

Camptothecin*

2 (0.12070)

3

2

2

 

Rapamycin*

6 (0.11533)

4

7

4

Sinomenine

Matrine

4 (0.10923)

6

3

11

 

Honokiol

8 (0.10142)

5

9

16

 

Luteolin

10 (0.10007)

11

17

6

 

Quercetin

14 (0.09835)

20

5

3

 

Paeoniflorin

29 (0.08215)

26

29

31

  1. *: Agent pairs with known synergistic effects.
  2. #: For each given agent, there are totally 62 candidate agent pairs. PPI, protein-protein interaction network. KNC, Keep Node Content pathway network. MNC, Merge Node Content pathway network.