Simulation results for cell apoptosis ( f
( t )) (A) Time course for the cell apoptosis induced in Jurkat cells following exposure to 50ng/ml TRAIL. The control time point in the experiment corresponds to 3 h at the simulation. Experimental data were analyzed using a FACSCalibur flow cytometer (Figure S1 in the Supplemental Material). The inset shows the time course for the apoptosis rate. (B) Simulation results of cell apoptosis for Jurkat cells incubated with increasing concentrations of death stimuli 16 h. Experimental data were retrieved from , Fig. 5. The parameters used included: rpro = 0, r0 = 3.31 × 10-6s-1, τ
= 11hr, p = 1.05 × 10-8s-1, K4 = 55.00nM, n = 4.0, and [TNF] = 1.0nM to mimic 50 ng/ml TRAIL. The proliferation rate was assumed to be zero based on the arrest of cell proliferation observed during the experimental period.