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Table 1 Rate expressions and parameters

From: A trigger model of apoptosis induced by tumor necrosis factor signaling

Rate Rate expression Parameters
Association of TNF to the receptor TNF-R, kon = 9.09 × 10-5 nM-1s-1
Dissociation of TNF, koff= 1.00 × 10-4s-1
Activation of Casp8 through DISC, v1 = 2.65 × 10-3s-1
K1 = K2 = 50nM
Activation of Casp3 directly, v2 = 6.00 × 10-5nM-1s-1
Activation of Casp3 through mitochondria, v3 = 2.60 × 10-4s-1
[Casp9]0 = 20nM
K3 = 8nM
τ = 30min
Synthesis rate vCasp8 = 6.67 × 10-4nMs-1
vCasp3 = 4.00 × 10-5nMs-1
Degradation rate dcasp8 = 2.00 × 10-5s-1

dcasp3 = 2.00 × 10-7s-1
dCasp3* = 2.40 × 10-4s-1