TF-regulatory network in 4w GK. In total, 12 genes were found to be differently expressed between GK and WKY. The nodes are colored by the same way as Figure 1. The node form depends on the expression degree between GK and WKY: bold node means genes that are overexpressed comparing GK to WKY, while dash-line node means genes which expression levels are lower in GK than that in WKY. At the beginning of hyperglycemia, inflammation, bile metabolism dysfunction, decreased proliferation and increased apotosis already show in GK rats liver at 4 weeks of age.