Possible linkages between the inner and outer cellular states of human induced pluripotent stem cells

BMC Systems Biology

Table 1 Relationships between glycosyltransferase expression, network, and glycan signature

Glycosyltransferase	Functions	Glycan structure
ST6GAL1	N-, O-Glycan and glycolipid biosynthesis	Siaa2,6Galb1,4GlcNAc-R
B3GNT3	O-Glycan biosynthesis	core1 extension
GCNT2	N-, O-Glycan and glycolipid biosynthesis	I antigen Siaa2,3Galb1,3GalNAca1-
ST3GAL1	O-Glycan biosynthesis	Ser/Thr
FUT2	N-, O-Glycan and glycolipid biosynthesis	H antigen
GALNT6	O-Glycan biosynthesis	GalNAca1-Ser/Thr
GALNT8	O-Glycan biosynthesis	GalNAca1-Ser/Thr
GALNT10	O-Glycan biosynthesis	GalNAca1-Ser/Thr
GALNT12	O-Glycan biosynthesis	GalNAca1-Ser/Thr
GALNT14	O-Glycan biosynthesis	GalNAca1-Ser/Thr
GALNTL2	Unknown
B3GALT5	N-, O-Glycan and glycolipid biosynthesis	Galb1,3GlcNAc-R, SSEA-3
B3GALT1	N-, O-Glycan and glycolipid biosynthesis N- and O-Glycan, keratan sulfate	Galb1,3GlcNAc-R
B3GNT2	biosynthesis	polylactosamine

The fourteen glycosyltransferases with identified correspondences between expression, network, and glycan signatures were allocated to biosynthetic pathways, using the KEGG GLYCAN database with modifications. The names of the pathways are listed. See also additional file 12 for the detailed pathways of notable glycosyltransferases, according to the KEGG GLYCAN database.

ISSN: 1752-0509