Functional pathway mapping analysis for hypoxia-inducible factors

BMC Systems Biology

Table 1 Statistics of the OrthRate and ParaRate parameters within mapped functional pathways between 2 model species with humans as the reference

	Phylogeny	OrthNum	OrthRate	ParaNum	ParaRate
HSA	1	14	N/A	24	N/A
MMU	2	14	14/14 (100%)	26	26/24 (108.3%)
GGA	3	13	13/14 (92.9%)	20	20/24 (83%)
XTR	4	9	9/14 (64.3%)	8	8/24 (33%)
DRE	5	12	12/14 (85.7%)	23	23/24 (95.8%)
CIN	6	9	9/14 (64.3%)	9	9/24 (37.5%)

The first column, Phylogeny, shows the evolutionary distance from HSA to the other 5 model species. OrthNum represents the total number of genes involved within the subpathway of HIF responses, and OrthRate represents the functional conservation of the HIF pathway between 2 species (with HSA as the reference species). ParaNum shows the total number of paralogous genes involved within the subpathway of HIF responses, and ParaRate represents the relative possibility of gene replacement within the HIF functional pathway between 2 species (with HSA as the reference species). HSA, H. sapiens; MMU, M. musculus; GGA, G. gallus; DRE, D. rerio; XTR, X. tropicalis; CIN, C. intestinalis.

ISSN: 1752-0509