Figure 2

Combining genetic interaction and co-expression data to define co-functional gene pairs. High correlation coefficient (A) and extreme S-Score both correspond with known co-functional gene pairs in Gene Ontology (GO) (bin size is 1 Correlation and 1.5 for S-Score). (C) Gene pairs have more extreme S-score and larger correlation of expression have higher enrichment. (D) When combining two criteria, the enrichment is significantly improved in extreme S-score and large correlation area.