Screenshots for the keyword search page and a gene and variant information page in SigCS base web interface. The keyword search for the stroke and its etiology related genetic variant information in SigCS base is available at the keyword search page. Some useful user options including simple logical combination, limitation of search in terms of the existence of variants, batch search, and a multiple selection of etiologies to be searched are provided (Panel A). Gene and variant information page shows a gene information table, an OMIM-originated variant table, a UniProt-originated variant table, and a dbSNP-originated variant table (Panel B). In the figure, only the gene information table and an OMIM-originated variant table are shown.