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Table 1 Drug target prediction examples by the DRS

From: Drug-drug relationship based on target information: application to drug target identification

Drug Name Known Targets Score (frequency for score ties) from the positive drug-pairs Rank Score (frequency for score ties) from the newly predicted drug-pairs (not sharing a target) Rank
DMT (DB01488) 5-HT7
5-HT1B
5-HT5A
5-HT6
5-HT1D
5-HT1A
σ1
5-HT2A
5-HT2C
5-HT2B
0.858(10)
0.858(14)
NA
0.858(6)
0.858(16)
0.910
0.772
0.942(63)
0.942(32)
0.882
40
39
NA
42
38
17
52
1
3
32
0.426
0.778(4)
NA
NA
0.778(4)
0.529(2)
NA
NA
0.376
0.778(2)
75
3
NA
NA
3
45
NA
NA
99
5
  K+ 0.939 [Potassium H2] 16 0.655 [Potassium D2,D3,KQT2,A1] 28
  hERG NA NA NA NA
  D2 0.961(63) 1 NA NA
Motilium (DB01184) D3 0.917 22 NA NA
  α1 α1A 0.961(26) 4 α1B 0.700(1) 18
   α1B 0.961(20) 7 α1A 0.694 20
  5(HT2A) 0.961(41) 2 0.752 10
  VMAT2 0.878 1 NA NA
Xenazine (DB04844) α2 α2A 0.807 14 α2A 0.706 4
   α2B 0.758 15 α2B 0.650 37
Prantal (DB00729) δ
M3
0.975
0.986
21
1
0.830
NA
49
NA
  M1 0.954(71) 1 NA NA
  M2 0.954(58) 2 NA NA
  M3 0.954(53) 3 NA NA
  β1- 0.918 [β1 adrenergic receptor] 31 0.635 [β1 adrenergic receptor] 24
Paxil (DB00715) DAT 0.951(24) 10 0.775 4
  NET 0.951(45) 6 NA NA
  5-HTT 0.951(42) 7 NA NA
  α1 α1A 0.951(41) 8 α1A 0.687 15
   α1B 0.939 12 α1B 0.545 60
Prozac (DB00472) 5HTT
NET
β1-
CA
H1
5-HT2C
5-HT2A
M1
0.992(42)
0.992(32)
0.988 [β1 adrenergic receptor]
NA
0.992(25)
0.991(35)
0.992(63)
0.992(23)
2
4
18
NA
5
14
1
6
NA
0.861
0.699 [β1 adrenergic receptor]
CA2, 0.280
0.776
NA
NA
0.735(8)
NA
3
106
357
86
NA
NA
89
Rescriptor (DB00705) H4
HIVRT
*Gag-Pol
NA
NA
0.847
NA
NA
1
0.259
NA
NA
47
NA
NA
  PTGS2 0.923 1 NA NA
  PDPK1 0.746 21 NA NA
  CA2 NA NA 0.824 1
  Kv 0.505 [Kv subfamily C member 4] 177 0.451 [Kv subfamily KQT member 1] 47
     0.451 [Kv subfamily E member 1] 48
  1. Bold: new prediction by Keiser, under bar: known interaction in DrugBank, *: annotated in DrugBank but not in the study by Keiser, Abbreviations: 5HT, 5-hydroxytryptamine; 5-HTT, serotonin transporter; K+, potassium channel; hERG, human Ehter-a-go-go related gene channel; D1-4, Dopamine 1-4; α1-2, α adrenergics; VMAT2, vesicular monoamine transporter 2; δ, δ-opioid receptor, M1-3, muscarinics; β1-, adrenertic agonist; DAT, dopamine transporter; NET, noradrenaline transporter; CA, carbonic anhydrase, H1-4, histaminergics; HIVRT, HIV-1 reverse transcriptase; Gag-Pol, Gag-Pol polyprotein; PTGS2, Prostaglandin G/H synthase 2; PDPK1, 3-phosphoinositide-dependent protein kinase 1; Kv, voltage-gated potassium channels