A methodology for multivariate phenotype-based genome-wide association studies to mine pleiotropic genes

BMC Systems Biology

Table 2 Representative association rules

Rule #	Rule body		Rule head	Supp	Conf	Lift
	Rules encoding highTG levels
1	LDL5, BMI5, TG5, TCHL5	→	NONHDL5	0.0157	1.0000	5.1732
2	GLU1205, TCHL5, LDL5, TG5	→	NONHDL5	0.0136	1.0000	5.1732
3	LDL5, TG5, TCHL5, GLU05	→	NONHDL5	0.0132	1.0000	5.1732
4	TG5, PLAT5, LDL5, NONHDL5	→	TCHL5	0.0127	1.0000	5.1465
5	GLU605, TG5, TCHL5, LDL5	→	NONHDL5	0.0126	1.0000	5.1732
6	TG5, LDL5, TCHL5, DS1	→	NONHDL5	0.0122	1.0000	5.1732
7	LDL5, INS1205, TCHL5, TG5	→	NONHDL5	0.0119	1.0000	5.1732
8	DBP5, TG5, LDL5, TCHL5	→	NONHDL5	0.0119	1.0000	5.1732
9	INS605, TCHL5, TG5, LDL5	→	NONHDL5	0.0116	1.0000	5.1732
10	TG5, TCHL5, INS05, LDL5	→	NONHDL5	0.0107	1.0000	5.1732
11	TG5, LDL5, SBP4, TCHL5	→	NONHDL5	0.0107	1.0000	5.1732
12	TG5, TCHL5, WHR5, LDL5	→	NONHDL5	0.0107	1.0000	5.1732
13	T_HDL5, NONHDL5, LDL4, HDL2	→	TG5	0.0102	0.8875	4.1105
14	TCHL2, LDL1, NONHDL2, PH1	→	TG5	0.0100	0.8333	3.8595
	Rules encoding highLDL levels
15	TCHL5, NONHDL5, GLU605	→	LDL5	0.0405	0.8324	4.2651
16	DS1, NONHDL5, GLU605	→	LDL5	0.0155	0.8182	4.1924
17	NONHDL5, SONA4, TCHL5	→	LDL5	0.0242	0.8450	4.3297
18	TG3, BUN5, NONHDL5	→	LDL5	0.0114	1.0000	5.1239

ISSN: 1752-0509