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Table 3 Genetic variants associated with highLDLhighTG

From: A methodology for multivariate phenotype-based genome-wide association studies to mine pleiotropic genes

SNP Chr Base position SNP type gene Str- and Allele(+/-) Freq (+) P-value hLDLhTG OR mORPLDL mORPTG r2
rs11700112 20 9495018 nonsyn PAK7 - G C 0.31 6.2×10-5 1.44 3.25 1.58 1.00
rs6140956 20 9450080 intronic C20orf103 + C T 0.41 6.3×10-5 1.40 2.79 1.85 0.56
rs6133716 20 9455931 intronic C20orf103 + A G 0.40 1.0×10-4 1.39 2.58 1.75 0.59
rs9967942 20 9503781 intronic PAK7 - C A 0.34 9.6×10-5 1.41 3.24 1.76 0.89
rs11087847 20 9504159 intronic PAK7 - T G 0.31 8.6×10-5 1.43 3.02 1.59 0.99
rs2822994 21 15282928 intronic NRIP1 - A G 0.41 8.7×10-5 1.40 2.46 2.59 1.00
rs2822998 21 15285230 intronic NRIP1 - C A 0.41 4.1×10-4 1.35 2.09 2.12 0.97
rs1041404 21 15346738 intronic NRIP1 - A G 0.43 1.7×10-4 1.37 2.38 2.33 0.64
rs9959874 18 59045526 intronic BCL2 - A G 0.15 1.2×10-4 1.60 3.40 2.20 1.00
rs1893506 18 59044660 intronic BCL2 - G A 0.15 1.5×10-4 1.59 3.31 2.08 1.00
rs4744611 9 72551280 intronic TRPM3 - G A 0.49 1.8×10-4 1.36 1.93 3.14 1.00
rs7039780 9 72469777 intronic TRPM3 - G A 0.50 3.7×10-4 1.34 1.57 2.98 0.90
rs4744608 9 72470797 intronic TRPM3 - G C 0.50 3.7×10-4 1.34 1.52 2.99 0.90
rs665770 1 200014747 intronic NAV1 + A G 0.38 2.0×10-4 1.38 2.65 1.54 1.00
rs529581 1 200016143 intronic NAV1 + C G 0.37 2.0×10-4 1.38 2.59 1.59 0.99
rs693 2 21085700 coding APOB - A G 0.07 7.3×10-4 1.83 0.04 2.21 -
  1. SNP rs693 reported in a previous study (Kathiresan, et al, 2008) for associations between high TG and high LDL. The rs693 was pruned since its effect was stronger in single traits high LDL than multivariate highLDLhighTG with borderline significance.