Figure 1

Examples of simulated associations. a. An example of simulated time-delayed association series with five replicates is shown, where X (red square) leads Y (blue circle) by three time units. The pattern is not significant by ordinary correlation analysis (PCC=-0.258, P=0.272); however, it is captured by local similarity analysis (LS=0.507, P=0.006). b. An example of simulated subinterval association series with five replicates is shown, where X (red square) and Y (blue circle) are associated in the time interval from 6 to 15. The pattern is not significant by ordinary correlation analysis (PCC=0.258, P=0.273); however, it is captured by local similarity analysis (LS=0.428, P=0.028).