Conceptual relationship of clinical and genetic factors. Colors in the box denote different levels of data. Lines are drawn in different shapes according to different degrees of certainty. After primary tumor occurred, accumulated (epi)genetic mutations drive cancer progression. With transcriptional level data, we can elucidate lymph node invasion (A) and cancer prognosis (C). But in the prediction steps, the previously proven relation between D and F should be properly explained (B).