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Table 2 Graph centrality based breast cancer signatures

From: Integration of breast cancer gene signatures based on graph centrality

BC CC DC EC IC SC
TP53 TP53 TP53 TP53 TP53 TP53
EGFR ESR1 EGFR ESR1 EGFR ESR1
CTNNB1 AR EP300 EP300 EP300 EP300
SMAD3 EGFR ESR1 AR ESR1 AR
ESR1 EP300 BRCA1 BRCA1 BRCA1 BRCA1
EP300 SMAD3 CREBBP CREBBP CREBBP CREBBP
SRC BRCA1 SMAD3 SMAD3 AR SMAD3
BRCA1 CTNNB1 AR EGFR SMAD3 EGFR
CREBBP SRC CTNNB1 HDAC1 SRC HDAC1
AR CREBBP SRC STAT3 CTNNB1 STAT3
UBE2I AKT1 HDAC1 RB1 HDAC1 RB1
DYNLL1 HDAC1 CASP3 CTNNB1 RB1 CTNNB1
CASP3 STAT3 RB1 JUN PIK3R1 JUN
ACTB STAT1 PIK3R1 SRC CASP3 SRC
AKT1 XRCC6 STAT3 AKT1 STAT3 AKT1
HDAC1 RB1 UBE2I SMARCA4 AKT1 SMARCA4
PIK3R1 PIK3R1 AKT1 CDKN1A SHC1 CDKN1A
ZBTB16 PML CDK2 PML CDK2 PML
ACVR1 UBE2I PCNA STAT1 JUN STAT1
RB1 HSPA8 SHC1 CDK2 STAT1 CDK2
STAT1 CASP3 JUN NCOA6 UBE2I NCOA6
HGS CDK2 DYNLL1 HDAC2 CDKN1A HDAC2
CDK2 SMARCA4 STAT1 PIK3R1 PCNA PIK3R1
YWHAZ CDKN1A ACTB UBE2I HDAC2 UBE2I
BCL2 JUN CDKN1A XRCC6 SMARCA4 XRCC6
XRCC6 CDH1 MAPK14 HIF1A NFKB1 HIF1A
STAT3 YWHAZ YWHAZ NFKB1 CDH1 NFKB1
PLK1 MAPK14 BCL2 CASP3 ACTB CASP3
PCNA PRKDC HDAC2 E2F1 MAPK14 E2F1
HSPA8 HIF1A ATM CEBPB LYN CEBPB
FN1 SHC1 LYN PRKDC XRCC6 PRKDC
VIM STUB1 NFKB1 SHC1 ATM SHC1
CD44 HDAC2 XRCC6 NCOA2 ZBTB16 NCOA2
MAPK14 ERBB2 CDH1 CCND1 E2F1 CCND1
GNB2L1 HSPA4 SMARCA4 PCNA YWHAZ PCNA
FANCA BCL2 EZR TDG BCL2 TDG
EEF1A1 ZBTB16 HGS ERBB2 PML ERBB2
SKIL LYN ZBTB16 HSPA4 JAK1 HSPA4
SHC1 NCOA6 PLK1 ZBTB16 EZR ZBTB16
USP7 PAK1 CAV1 RXRA PRKDC RXRA
CAV1 MDM4 E2F1 MAPK14 JAK2 MAPK14
JUN CASP8 JAK1 JAK2 CASP8 JAK2
RXRA CEBPB RXRA STUB1 RXRA STUB1
LYN NFKB1 FN1 CDK7 ERBB2 CDK7
CDKN1A JAK2 HSPA8 PTPN6 HIF1A PTPN6
HIF1A PTPN6 VAV1 ATM CAV1 ATM
ATM HGS ACVR1 BCL3 HSPA8 BCL3
EZR EZR CASP8 DDX5 VAV1 DDX5
PPP1CA CAV1 HIF1A RBL1 CDKN2A RBL1
PAK1 PIAS4 JAK2 FOS NCOA6 FOS
PLSCR1 TDG PML CDH1 PTPN6 CDH1
TGFBR2 IGF1R CDKN2A MDM4 DYNLL1 MDM4
AURKA DDX5 EEF1A1 ING1 HGS ING1
KPNB1 MET ERBB2 SIN3A SIN3A SIN3A
  1. 54 genes with highest graph centrality in the context-constrained PIN are selected to consist new breast cancer gene signatures. The genes in the six signatures identified by six graph centrality measurements are listed in this table.