Pathway crosstalk and functional map of DEPgenes (major depressive disorder genes). In this figure, each node represents a significant pathway, and each edge represents a pathway crosstalk, i.e., a significant overlap of the component genes between two linked pathways. The color of each node is approximately proportional to the adjusted P (PBH) value of the corresponding pathway in the pathway enrichment analysis by Ingenuity Pathway Analysis (IPA). Darker color indicates lower PBH value. The size of each node is approximately proportional to the number of DEPgenes found in the corresponding pathway. The width of each edge is approximately proportional to the overlap score of the related pathways (see Materials and methods).