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Table 1 Gene Ontology (GO) terms enriched with module genes (GO level ≥ 4)

From: A comprehensive network and pathway analysis of candidate genes in major depressive disorder

GO terms Observed* P P BH $
Biological process    
GO:0007268: synaptic transmission 45 7.18 × 10-38 1.18 × 10-34
GO:0007267: cell-cell signaling 56 8.78 × 10-37 7.21 × 10-34
GO:0019226: transmission of nerve impulse 46 2.84 × 10-36 1.55 × 10-33
GO:0044057: regulation of system process 36 1.23 × 10-29 2.89 × 10-27
GO:0051239: regulation of multicellular organismal process 55 1.07 × 10-29 2.89 × 10-27
GO:0050877: neurological system process 59 4.72 × 10-26 9.69 × 10-24
GO:0007154: cell communication 103 6.14 × 10-26 1.12 × 10-23
Molecular function    
GO:0008227: G-protein coupled amine receptor activity 15 5.13 × 10-21 7.18 × 10-19
GO:0035240: dopamine binding 7 2.25 × 10-13 1.58 × 10-11
GO:0005230: extracellular ligand-gated ion channel activity 12 4.17 × 10-12 2.34 × 10-10
GO:0004888: transmembrane receptor activity 40 6.55 × 10-12 2.78 × 10-10
GO:0005102: receptor binding 31 9.87 × 10-11 3.07 × 10-9
GO:0022834: ligand-gated channel activity 13 2.46 × 10-10 5.74 × 10-9
Cellular component    
GO:0043005: neuron projection 30 2.43 × 10-22 3.91 × 10-20
GO:0044459: plasma membrane part 61 3.12 × 10-20 2.51 × 10-18
GO:0000267: cell fraction 45 1.45 × 10-19 7.78 × 10-18
GO:0005887: integral to plasma membrane 47 5.84 × 10-19 2.35 × 10-17
GO:0031226: intrinsic to plasma membrane 47 1.27 × 10-18 4.09 × 10-17
GO:0042995: cell projection 35 5.50 × 10-18 1.48 × 10-16
GO:0005886: plasma membrane 80 1.64 × 10-17 3.77 × 10-16
GO:0030424: axon 18 1.15 × 10-15 2.31 × 10-14
GO:0030425: dendrite 17 2.76 × 10-14 4.94 × 10-13
GO:0005626: insoluble fraction 32 7.11 × 10-13 1.14 × 10-11
  1. *Number of the observed DEPgenes in the category.
  2. $P values were adjusted by Benjamini & Hochberg (BH) method [34].