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Table 2 Canonical pathways enriched with module genes by Ingenuity Pathway Analysis (IPA) (PBH < 10-6)

From: A comprehensive network and pathway analysis of candidate genes in major depressive disorder

Ingenuity canonical pathways Observed* P BH $
cAMP-mediated signaling 23 6.31 × 10-16
G-protein coupled receptor signaling 31 5.01 × 10-15
Serotonin receptor signaling 12 6.31 × 10-15
Corticotropin releasing hormone signaling 14 7.94 × 10-11
Dopamine receptor signaling 11 3.80 × 10-9
Glucocorticoid receptor signaling 17 1.35 × 10-8
PXR/RXR activation 10 2.29 × 10-8
Amyotrophic lateral sclerosis signaling 11 5.89 × 10-8
Neuropathic pain signaling on dorsal horn neurons 11 5.89 × 10-8
Relaxin signaling 12 1.02 × 10-7
CREB signaling in neurons 13 1.62 × 10-7
Tryptophan metabolism 11 6.61 × 10-7
  1. *Number of the observed DEPgenes in the category.
  2. $P values were adjusted by Benjamini & Hochberg (BH) method [34].