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Table 2 Canonical pathways enriched with module genes by Ingenuity Pathway Analysis (IPA) (PBH < 10-6)

From: A comprehensive network and pathway analysis of candidate genes in major depressive disorder

Ingenuity canonical pathways

Observed*

P BH $

cAMP-mediated signaling

23

6.31 × 10-16

G-protein coupled receptor signaling

31

5.01 × 10-15

Serotonin receptor signaling

12

6.31 × 10-15

Corticotropin releasing hormone signaling

14

7.94 × 10-11

Dopamine receptor signaling

11

3.80 × 10-9

Glucocorticoid receptor signaling

17

1.35 × 10-8

PXR/RXR activation

10

2.29 × 10-8

Amyotrophic lateral sclerosis signaling

11

5.89 × 10-8

Neuropathic pain signaling on dorsal horn neurons

11

5.89 × 10-8

Relaxin signaling

12

1.02 × 10-7

CREB signaling in neurons

13

1.62 × 10-7

Tryptophan metabolism

11

6.61 × 10-7

  1. *Number of the observed DEPgenes in the category.
  2. $P values were adjusted by Benjamini & Hochberg (BH) method [34].