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Figure 1 | BMC Systems Biology

Figure 1

From: Bayesian parameter estimation for nonlinear modelling of biological pathways

Figure 1

Temporal profiles of macrophage numbers, IL-10 concentrations, and TGF-β concentrations post myocardial infarction establish the nonlinear dynamic patterns of the MI response. A: Temporal profile of macrophage infiltration (cell numbers/mm2) post myocardial infarction reconstructed from experimental data in C57 mice [21]. B: Temporal profile of IL-10 concentrations (pg/ml) post myocardial infarction reconstructed from experimental data in C57 mice [19, 20]. C: Temporal profile of TGF-β computed based on the nonlinear dynamics equation (24). D: Sampled TGF-β profile in part C to represent the sparse experimental data on TGF-β concentrations.

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