Skip to main content
Figure 1 | BMC Systems Biology

Figure 1

From: Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organisms

Figure 1

Known heterologous reactions leading to the production of liquiritigenin (white circular node). Squares represent reactions and circular nodes represent molecules. Dark green nodes are present in the host organism, E. coli K-12, light green can be produced via enzyme catalyzed reactions and red ones cannot. Liquiritigenin, a highly selective estrogen receptor β agonist, is represented by the white node v1. Side products not consumed in this pathway are not represented for simplicity. Four pathways lead from the host compounds to the production of the target molecule, one for instance is the pathway involving reactions R1, R2, R4, R7. Legend: v1: liquiritigenin, v2: ATP, v3: NADH, v4: NADPH, v5: NADP+, v6: oxygen, v7: CoA, v8: acetate, v9: H+, v10: L-tyrosine, v11: malonyl-CoA, v12: 4-hydroxybenzoate, v13: trans-cinnamate, v14: p-coumaroyl-CoA, v15: cinnamoyl-CoA, v16: 4-coumarate, v17 isoliquiritigenin, v18: cinnamaldehyde, v19: 3-(4-hydroxyphenyl)lactate, v20: 4-hydroxycinnamyl aldehyde.

Back to article page