i

Gene deletion

Reaction deletion

f
_{
i
}
 

1

GR2

GR5a

R2

R5

R10

308.2

*

2

GR2

GR5b

R2

R5

R10

308.2

*

3

GR2

GR11

R2

R10

R11

308.2

*

4

GR2
 
R2

R9

R10

211.2
 
 List of all MCS for the regulatory BLP. MCS are sorted in decreasing order of the objective function ${f}_{i}={w}_{2}^{T}{x}^{\left(i\right)}+\left\right{y}^{\left(i\right)}\left\right$ as calculated by our algorithm. (The sequence of MCS with equal objective value may differ depending on the BLP algorithm.) * marks MCS for which full genetic information is available. MCS are split in the gene deletion part and the reaction deletion part. Note that the first three MCS require deletions of two genes. The corresponding reaction deletions are a consequence of those deletions. MCS 4 however, is not fully annotated (noticeable in the drop of f_{
i
}), and would require the deletions of genes and reactions (GR2 and R9).