Nine types of changes in the flux patterns based on combinations of positive and negative changes in V
. Types 1, 2, and 3 have the amplification candidates positively correlated with the production of a target chemical. Types 4, 5, and 6 were negatively correlated with the target product. Types 7, 8, and 9 did not show unique patterns with the enforced fluxes towards the target chemical. Nine possible combinations of flux bias ( V
) and flux capacity (l
) for each reaction were investigated, and displayed on the bottom of the figure.