Table 1 Ranges considered for six classes of model parameters
Parameter class | Estimated range | Units |
|---|---|---|
Rate constant for a bimolecular association reaction | 10-7 – 10-5 | (molecules/cell)-1·s-1 |
Rate constant for a unimolecular dissociation reaction | 10-2 – 100 | s-1 |
Rate constant for a phosphatase-catalyzed reaction* | 10-3 – 10-1 | s-1 |
Rate constant for a receptor trafficking step (internalization or recycling)* | 10-3 – 10-1 | s-1 |
Rate constant for endocytic degradation* | 10-3 – 10-1 | s-1 |
Protein copy number | 104 – 106 | molecules/cell |